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Dynamic changes of macrophage polarization during Salmonella infection in zebrafish

ABSTRACT: To investigate the polarization status of macrophages during salmonella persistent infection we established a model of Salmonella enterica serovar Thyphimurium infection in the zebrafish larva in which salmonella survive long term inside the host. In this model, during initial stages of the infection, macrophages are recruited to the infection site and express tnfa. By contrast, in the late stages of the infection, macrophages form clusters at the infection site and do not express tnfa. The objective is to characterize the transcriptional profile of macrophages in early stage of infection (4 hours post-infection) and late stage of infection (4 days post-infection).

ORGANISM(S): Danio rerio

PROVIDER: GSE224985 | GEO | 2024/01/25

REPOSITORIES: GEO

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Transcription profiling of Salmonella enterica serovar Typhimurium strains with mutations in three SPI-2 co-expressed tested for their ability to cause disease in mice

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2013-10-07 | PXD000389 | Pride

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