Role of mitochondrial RNase P complex in the processing of primary RNA in human mitochondria

ABSTRACT: The human mitochondrial genome is transcribed into long polycistronic RNA that undergoes subsequent endonucleolytic processing. The role of the mitochondrial RNase P, a protein complex composed of RNA methyltransferase, ribonuclease and dehydrogenase, has been revealed in the processing of the primary mitochondrial RNA. Still, the contribution of catalytic activities of RNase P subunits in the processing of individual processing sites has not been fully described. This study aims to define the role of RNase P subunits in regulating the efficiency of the processing of the primary mitochondrial RNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE235890 | GEO | 2026/06/27

REPOSITORIES: GEO