Transcriptomic changes in Grin2b-C456Y-mutant mice with NMDAR activation

ABSTRACT: Our previous study reported a Grin2b-mutant mouse line carrying a point mutation identified in individuals with ASD (Grin2b+/C456Y mice), which show suppressed long-term depression and anxiolytic-like behavior that are responsive to early chronic D-cycloserine (DCS) treatment (postnatal day 7 to 16) for pharmacological activation of NMDARs. To figure out the rescue mechanism, we attempted RNA-Seq analysis of wild-type (WT) and Grin2b+/C456Y mice that are early and chronically treated with vehicle and DCS.

ORGANISM(S): Mus musculus

PROVIDER: GSE237027 | GEO | 2026/07/09

REPOSITORIES: GEO