Hepatic stellate cell-derived thrombospondin-2 as a novel therapeutic target for liver fibrosis

ABSTRACT: The in vivo effects of silencing Thbs2 in hepatic stellate cells (HSCs) were examined using an adeno-associated virus vector (serotype 6, AAV6) containing short hairpin RNAs (shRNAs) targeting Thbs2, under the regulatory control of cytomegalovirus (CMV) or smooth muscle α-actin (αSMA) promoter, in carbon tetrachloride (CCl4) induced liver fibrosis mouse models. Bulk RNA-seq of liver tissues from AAV6-CMV-shThbs2 mice or AAV6-αSMA mice and their controls was performed.

ORGANISM(S): Mus musculus

PROVIDER: GSE245857 | GEO | 2026/04/01

REPOSITORIES: GEO