Transcriptional failures arrest development after human nuclear transfer

ABSTRACT: Reprogramming occurs after nuclear transfer into zygotes whose genomes have been removed in mitosis, but not after nuclear transfer into zygotes enucleated in interphase. Our results suggest that there is a previously unappreciated barrier to successful human nuclear transfer, and that future studies should focus on the requirements for somatic genome activation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE24631 | GEO | 2011/10/04

SECONDARY ACCESSION(S): PRJNA132461

REPOSITORIES: GEO