Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-nucleus transcriptome sequencing reveals the identity of neurons that respond to the panic attack.

ABSTRACT: In nature, moderate innate defensive behaviors (e.g. escaping and freezing) are commonly triggered by imminent threats in human and animal, accompanied with series of physiological responses related with activation of autonomic nervous system (e.g. tachycardia，increased blood pressure, tachypnea). According to many prior researches, posterior hypothalamic nucleus (PHN) with highly cell diversity is recognized to be connected tightly with panic attack. However, the neural substrate of sub-clusters of this important hypothalamic nucleus in panic attack-related defensive behavior has not yet elucidated. In order to justify the hypothesis, we adopted snDNA-seq to screen out a main population, Cbln2+ neurons, manipulating panic attack behaviors in PHN. Subsequently, we illustrated the neural coding mechanism of Cbln2+ PHN neurons for threats stimulus, and indicated the neurobiological functions of neural network of PHN neurons in defensive behaviors. In conclusion, our data suggested that Cbln2+ PHN neurons is sufficient and necessary to regulate panic attack related defensive behaviors in mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE252356 | GEO | 2025/07/09

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

A vagal-brainstem interoceptive circuit for cough-like defensive behaviors in mice

Project description:Respiratory defensive behaviors, like coughing, play a crucial role in protecting the respiratory system, ensuring its integrity and optimal function. How these critical behaviors are regulated by sensory stimuli within the body remains largely unknown. Here, we show that the nucleus of the solitary tract (NTS) in mice, a key hub in the brain for processing internal sensory signals and mediating interoceptive processes, contains heterogenous neuronal populations that differentially control breathing. Within these subtypes, activation of tachykinin 1 (Tac1) neurons triggers a specific respiratory behavior. Our detailed characterization of respiratory defensive behaviors reveals that these responses are cough-like behaviors. Chemogenetic silencing or genetic ablation of Tac1 neurons significantly reduces cough-like behaviors induced by tussive challenges. These Tac1 neurons receive synaptic inputs from the bronchopulmonary chemosensory and mechanosensory neurons in the vagal ganglion, and directly integrate the medullary regions to control sequential phases of cough-like defensive behaviors. We propose that these Tac1 neurons are a key component of the airway-vagal-brain neural circuit that controls cough-like defensive behaviors in mice, and they coordinate the downstream modular circuits to elicit the sequential motor pattern of forceful expiratory responses.

2024-06-05 | GSE268741 | GEO

Single-nucleus transcriptome sequencing reveals the identity of neurons that respond to the panic attack.

Project description:Single-nucleus transcriptome sequencing reveals the identity of neurons that respond to the panic attack.

| PRJNA1060276 | ENA

DNA Methylation signatures in Panic Disorder

Project description:An Epigenome-Wide Association Study (EWAS) was conducted to compare medication-free panic disorder (PD) patients (n=89) with healthy controls (n=76) in peripheral blood samples.

2018-01-10 | GSE102468 | GEO

Microglia-like cells derived from patients with panic disorder

Project description:We used a model to induce patient-derived microglia-like cells (iMGs) to clarify the molecular characteristics and function of Panic disorder patient-iMGs (PD-iMGs). We established iMGs from 14 PD patients and 10 healthy controls (non-psychiatric controls, HC). We analyzed the phenotype of the PD-iMGs by RNA sequencing. The PD-iMGs clustered together distinct from HC-iMGs. Gene set enrichment analysis revealed the involvement of cholesterol biosynthesis and steroid metabolism in PD-iMGs.

2022-09-30 | GSE212802 | GEO

Single cell RNA-sequencing in the mouse central amygdala (CEA)

Project description:The central amygdala (CEA) is a brain region that consists of primarily GABAergic neurons. It has been widely investigated for its role in many innate and adaptive behaviors, such as appetitive and defensive behaviors. Despite the complex functions of CEA, the molecular diversity of CEA neurons has not been systemically examined. Here, we performed single-cell RNA-sequencing (scRNA-Seq) in the CEA to classify the molecularly defined neuron types in this region.

2023-02-03 | GSE213828 | GEO

Selective Vulnerability of Parvocellular Oxytocin Neuron in Social Dysfunction

Project description:Despite the rapid progress in dissecting neural circuits for social behaviors, it remains unknown whether specific neural cell types are selectively vulnerable in social dysfunction cases often associated with neurodevelopmental disorders. Here, employing a single-cell transcriptome analysis in mice, we show that an embryonic disturbance known to induce social dysfunction preferentially impairs gene expressions crucial for neural functions in parvocellular oxytocin (OT) neurons—a subtype linked to social rewards—while neighboring cell types experience a lesser impact. Chemogenetic stimulation of OT neurons at the neonatal stage ameliorated social deficits, concomitant with a cell-type-specific sustained recovery of the pivotal gene expressions. Our data illuminates the transcriptomic selective vulnerability within the hypothalamic social behavioral center, offering a potential therapeutic target through specific neonatal neurostimulation.

2023-12-05 | GSE245555 | GEO

Microglia-like cells derived from patients with panic disorder

Project description:Microglia-like cells derived from patients with panic disorder

| PRJNA877345 | ENA

Exposure-induced changes of plasma mRNA expression levels in patients with panic disorder

Project description:Anxiety disorders including panic disorders with or without agoraphobia are the most prevalent mental disorders. Exposure is a core technique within the framework of cognitive behavioral therapy to treat phobia- and anxiety-related symptoms. The primary aim of this study was to trace specific anxiety-related plasma gene expression changes of subjects with PD at three time points in order to identify biomarkers for acute anxiety states. In this intervention, the patient is exposed to highly feared and mostly avoided situations.

2018-09-15 | GSE119995 | GEO

RNA-seq of barley lines after dehydration, spider mite or combined stress.

Project description:Drought and herbivores are main threats to crop production. Barley plants were subjected to dehydration, spider mite attack or to a combination of both stresses. RNA-seq analyses were done to know how individual and double abiotic-biotic stresses promote changes in the transcriptome.

2018-04-30 | E-MTAB-6565 | biostudies-arrayexpress

Radosavljevic2009_BioterroristAttack_PanicProtection_1

Project description:This model is from the article: Epidemics of panic during a bioterrorist attack--a mathematical model. Radosavljevic V, Radunovic D, Belojevic G. Med Hypotheses 2009 Sep;73(3):342-6 19423234 , Abstract: A bioterrorist attacks usually cause epidemics of panic in a targeted population. We have presented epidemiologic aspect of this phenomenon as a three-component model--host, information on an attack and social network. We have proposed a mathematical model of panic and counter-measures as the function of time in a population exposed to a bioterrorist attack. The model comprises ordinary differential equations and graphically presented combinations of the equations parameters. Clinically, we have presented a model through a sequence of psychic conditions and disorders initiated by an act of bioterrorism. This model might be helpful for an attacked community to timely and properly apply counter-measures and to minimize human mental suffering during a bioterrorist attack. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

2024-09-02 | BIOMD0000000836 | BioModels

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data