Transcriptomics

Dataset Information

24

Effect of PDE4 inhibition on host gene expression of Mtb-infected mouse lungs.


ABSTRACT: Global gene expressions of Mtb-infected mouse lungs were compared between with and without PDE4 inhibitor treatment. A lot of host genes are differentially expressed 21d and 28d post-Mtb infection. PDE4 inhibitor, however, downregulate 10% of genes among those and genes differentially regulated by PDE4 inhibitor are mainly involved immune response. Overall design: Total RNA was isolated from Mtb-infected mouse lungs with or without CC-3052 (25 mg/kg/day) using Trizol reagent and gene profile was analyed using Affymetrix mouse ST 1.0

INSTRUMENT(S): [MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version]

ORGANISM(S): Mus musculus  

SUBMITTER: Mi-Sun Koo  

PROVIDER: GSE25313 | GEO | 2010-11-13

SECONDARY ACCESSION(S): PRJNA134885

REPOSITORIES: GEO

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