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Effect of traumatic brain injury on gene expression in bone.

ABSTRACT: It is clinically known, that patients often develop osteoporosis following traumatic brain injury (TBI). To enable a better understanding of the underlying mechanism, we developed a murine TBI model. Mice received a controlled cortical impact inducing a TBI. Expression analysis of the femur 3 days following the injury should reveal the regulated genes. We observed a strong downregulation of osteoblast genes, suggesting an inhibition of bone formation. Furthermore, the beta2-adrenoreceptor was downregulated, what is supposed to be induced by the increased adrenergic signaling in these mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE253133 | GEO | 2024/01/17

REPOSITORIES: GEO

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