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Applying a non-GMO breeding approach with an identified natural variation to reduce food allergen Len c3 in Lens culinaris seeds

ABSTRACT: Lentils (Lens culinaris) are produced in diverse agroecological regions and are consumed as one of the most important food legumes at world-wide. Lentils possess a nutritional profile from a human health perspective that is not only nutrient-dense but also offers a better balance between protein and carbohydrates. However, lentil causes food allergy which has been a significant concern due to increased consumption in parts of the world. Len c3, a none-specific Lipid Transfer Protein (LTP), was identified as one of the allergens in lentil seeds. In this study, we firstly identified the Len c3 encoding gene LcLTP3b via peptide sequence blasting. We then focused on screening natural variations to search for lentil germplasms that harbors natural mutated allergen-encoding genes. A natural variation 11 was identified with mutations at LcLTP3b and low accumulation of vicilin through genomic-assisted approaches. Furthermore, we generated a pool of lentil germplasms with Len c3-free background through crossing the identified natural variation 11 with two lentil cultivars, CDC Redmoon and CDC Gold. These Len c3-free lentil germplasms can be used as a breeding resource targeting at reducing allergen risk in lentil consumption.

ORGANISM(S): Lens culinaris

PROVIDER: GSE255951 | GEO | 2024/02/29

REPOSITORIES: GEO

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Project description:This ordinary differential equation model of the interactions between tumor and normal cells is based on the publication: S. A. Alharbi and A. S. Rambely, "Dynamic Simulation for Analyzing the Effects of the Intervention of Vitamins on Delaying the Growth of Tumor Cells," in IEEE Access, vol. 7, pp. 128816-128827, 2019 doi: 10.1109/ACCESS.2019.2940060. Comment: This TNM model is described by the system of equations presented in (2), in the publication manuscript. Abstract: The natural sources of the vitamins, which come from a balanced diet (as recommended by the World Cancer Research Fund and the American Institute for Cancer Research) contribute to protecting the body from advancing progressive of cancer stages. Thus, in this study, we analyze the effect of the intervention of vitamins on delaying the growth of cancer cells based on the dynamics of a normal cell cycle when the tumor cells appear in a tissue as a resulting for progressing abnormal cells due to the weak response of the immune system. We developed a mathematical model, called tumor-normal-vitamins model (TNVM), which is governed by a system of ordinary differential equations and refers to two main populations normal cells and tumor cells. This model considers the intervention of vitamins as a moderating factor within thirty days. The models are discussed analytically and numerically by utilizing the Runge-Kutta method to simulate them. The results of the analysis and simulation of free model illustrate that the model will be stable if the tumor cells succeed in eliminating normal cells in the tissue. Whereas, the analysis and simulation of the TNVM showed a case of coexistence between normal cells and tumor cells occur if an individual consumes a regular rate of vitamins that have been simulated to be 87% per day from a natural food source. Even though the response of the immune system is weak, the daily consumption of enough vitamins can play an essential role in delaying the development of an early stage of cancer. This study contributes to the increasing awareness regarding a healthy diet to reduce the risk of some deadly diseases, especially cancer.

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Applying a non-GMO breeding approach with an identified natural variation to reduce food allergen Len c3 in Lens culinaris seeds

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