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IL-17 signaling pathway and NMDAR1 antibodies shape NMDAR encephalitis

ABSTRACT: Human forebrain organoids (hFOs, day 110) derived from U2F iPS cell line were exposed with or without 10 μg/mL anti-NMDAR1 antibody for 24 hours. Organoids were then randomly selected for RNA sequencing (RNA-seq). By performing RNA-seq analysis, we showed that anti-NMDAR1 antibody exposure in hFOs downregulated expression of genes enriched with multiple neuronal functions including the glutamatergic synapse.These downregulated genes were also enriched with neuropsychiatric disorder-related genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE256148 | GEO | 2026/04/08

REPOSITORIES: GEO

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