Genomics

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Gene expression profiles of MCF7 with CARM1 knocked down


ABSTRACT: The goal of this study is to identify ERalpha-target genes affected by knocking down of the histone arginine methyltransferase CARM1 in MCF7 breast cancer cells. The roles of CARM1 in ERalpha+ breast cancer was not well characterized. Therefore, we created a Dox inducible CARM1 knockingdown MCF7 cell line where CARM1 is decreased to 20% of endogeneous level to determine the created a Dox-inducible CARM1shRNA overexpressing MCF7 cells for evaluation of the global effects of CARM1 on ERalpha-target gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE26259 | GEO | 2011/06/01

SECONDARY ACCESSION(S): PRJNA135097

REPOSITORIES: GEO

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