Transcranial ultrasound stimulation ameliorates DSS-induced colitis and behavioral disorders by suppressing the inflammatory response in the brain

ABSTRACT: This study explores the efficacy of transcranial ultrasound stimulation (TUS) in mitigating dextran sulfate sodium (DSS)-induced colitis and associated behavioral abnormalities in mice. TUS treatment significantly reduced colon inflammation and tissue damage while improving histological scores. Additionally, TUS alleviated anxiety- and depression-like behaviors, possibly by suppressing neuroinflammation via the downregulation of pro-inflammatory cytokines in both the colon and the brain. These findings suggest TUS as a promising non-invasive therapy for managing gut inflammation and associated behavioral disorders, highlighting its potential clinical implications.

ORGANISM(S): mouse gut metagenome

PROVIDER: GSE266180 | GEO | 2025/04/28

REPOSITORIES: GEO