Identification of the RNA that binds with FAK by high-throughput RIP-seq in MDA-MB-231 cells

ABSTRACT: FAK is overexpressed and aberrantly activated in various advanced solid tumors and plays a critical role in tumor progression and metastasis. Here, we identified an FAK-interacting lncRNA FAISL, FAISL (FAK Interacting and Stabilizing LncRNA) was frequently overexpressed in TNBC tissues and abundantly enriched in FAK-interacting lncRNAs. FAISL promotes cell adhesion, cytoskeleton spreading, proliferation and anchor-dependent survival of TNBC cells. FAISL doesn’t affect FAK mRNA but positively regulates the FAK protein level by blocking Calpain 2-mediated proteolysis, etc.

ORGANISM(S): Homo sapiens

PROVIDER: GSE268194 | GEO | 2026/05/01

REPOSITORIES: GEO