Effector differentiation and therapeutic reinvigoration of CD8+ T cells in chronic infection depend on KLF2-directed lymph node homing

ABSTRACT: In this study, we examine the heterogeneity and molecular regulation of CD8 T cells in chronic infection across lymph nodes and spleen. We find that lymph nodes, not the spleen, support the stemness and polyfunctionality of CD8 T cells and their response to PD-1 blocking therapy. We discover that the transcription factor KLF2 is specifically expressed in and required for stem-like precursor and effector-like T cells. Finally, we show that migratory dendritic cell in the lymph nodes support the differentiation and function of CD8 T cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE268824 | GEO | 2025/08/05

REPOSITORIES: GEO