MiR-208a-3p targets PPP6C to regulate the progression of Radiation-induced lung injury
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ABSTRACT: Aims: Radiation-induced lung injury (RILI) is a common complication after radiotherapy for clinical thoracic tumors, and increasing evidence suggests that miRNAs have potential value as biomarkers for early warning. However, the potential mechanism is still obscure. Here, we evaluated miRNAs-dependent mechanism involved in response and therapy of RILI. Results: Our data showed that mmu-miR-208a-3p was consistently highly expressed in the lung tissue of irradiated mice. In vitro studies demonstrated that the expression of miR-208a-3p in cells was significantly increased after X-ray irRadiation. Further mechanism studies indicated that Radiation-induced upregulation of miR-208a-3p promoted inflammatory responses by suppressing the expression of PPP6C and activating the cGAS/STING pathway. Overexpression of PPP6C can alleviate Radiation-induced DNA damage and excessive accumulation of ROS. It was also observed that PPP6C inhibited ionizing Radiation-induced pulmonary pneumonia in vivo. Innovation and Conclusion: miR-208a-3p/PPP6C represent a potential diagnostic marker and therapeutic target for Radiation-induced lung injury which needs to be verified by future clinical studies.
ORGANISM(S): Mus musculus
PROVIDER: GSE273437 | GEO | 2025/07/01
REPOSITORIES: GEO
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