Genomics

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Sarcopenia promotes tumorigenesis by disrupting Notch-SDC2-regulated biogenesis of muscle-derived extracellular vesicles


ABSTRACT: Studies using mouse xenograft and APCMin/+ models found that muscle acts as an anti-tumor organ by inhibiting tumor growth through muscle EVs. However, sarcopenic muscles exhibit reduced EV secretion and altered EV cargoes, promoting cancer progression. Our miRNA sequencing identified miR-7a-5p, a tumor-suppressor microRNA highly enriched in healthy muscle EVs but diminished in aging muscle EVs. miR-7a-5p targets TEAD1, suppressing its activity in tumors and inhibiting tumor growth.

ORGANISM(S): Mus musculus

PROVIDER: GSE276208 | GEO | 2025/12/18

REPOSITORIES: GEO

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