Sarcopenia promotes tumorigenesis by disrupting Notch-SDC2-regulated biogenesis of muscle-derived extracellular vesicles
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ABSTRACT: Studies using mouse xenograft and APCMin/+ models found that muscle acts as an anti-tumor organ by inhibiting tumor growth through muscle EVs. However, sarcopenic muscles exhibit reduced EV secretion and altered EV cargoes, promoting cancer progression. Our miRNA sequencing identified miR-7a-5p, a tumor-suppressor microRNA highly enriched in healthy muscle EVs but diminished in aging muscle EVs. miR-7a-5p targets TEAD1, suppressing its activity in tumors and inhibiting tumor growth.
ORGANISM(S): Mus musculus
PROVIDER: GSE276208 | GEO | 2025/12/18
REPOSITORIES: GEO
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