Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effect of isolated neutrophils from Cd177 knockout mice post-SCI on microglia in a co-culture system

ABSTRACT: To investigate the transcriptional effects of CD177+ neutrophils on microglia in spinal cord injuries (SCI), we adapted a co-culture system containing isolated neutrophils from Cd177 WT or KO mice post-SCI and isolated microglia. Each group had a biological repeat (n=3).

ORGANISM(S): Mus musculus

PROVIDER: GSE276429 | GEO | 2024/09/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Effect of isolated neutrophils from Cd177 knockout mice post-SCI on macrophages in a co-culture system

Project description:To investigate the transcriptional effects of CD177+ neutrophils on macrophages in spinal cord injuries (SCI), we adapted a co-culture system containing isolated neutrophils from Cd177 WT or KO mice post-SCI and bone marrow-derived macrophages (BMDMs). Each group had a biological repeat (n=3).

2024-09-10 | GSE276427 | GEO

Effect of isolated neutrophils from Cd177 knockout mice post-SCI on microglia in a co-culture system

Project description:Effect of isolated neutrophils from Cd177 knockout mice post-SCI on microglia in a co-culture system

| PRJNA1157350 | ENA

CD177+ neutrophils to restrict neuroinflammation following CNS injury

Project description:Neutrophils are the most abundant circulating leukocyte population that play critical roles in neuroinflammation after ischemic stroke. CD177, a glycoprotein on neutrophils, is emerging as an important immune regulator which fundamentally affects multiple inflammatory diseases. However, the role and regulatory mechanism of CD177 protein of neutrophils in neuroinflammation remains elusive. Using single-cell RNA sequencing (scRNA-Seq), we characterized CD177high neutrophils as a novel anti-inflammatory subset in response to ischemic stroke.

2025-03-27 | GSE293098 | GEO

Effect of isolated neutrophils from Cd177 knockout mice post-SCI on macrophages in a co-culture system

Project description:Effect of isolated neutrophils from Cd177 knockout mice post-SCI on macrophages in a co-culture system

| PRJNA1157347 | ENA

CD177+ neutrophils to restrict neuroinflammation following CNS injury

Project description:CD177+ neutrophils to restrict neuroinflammation following CNS injury

| PRJNA1242790 | ENA

Generation of pancreatic β cells from CD177+ anterior definitive endoderm

Project description:Methods for differentiating human pluripotent stem cells to pancreatic and liver lineages in vitro have been limited by the inability to identify and isolate distinct endodermal subpopulations specific to these two organs. Here we report that pancreatic and hepatic progenitors can be isolated using the surface markers CD177/NB1 glycoprotein and inducible T-cell costimulatory ligand CD275/ICOSL, respectively, from seemingly homogeneous definitive endoderm derived from human pluripotent stem cells. Anterior definitive endoderm (ADE) subpopulations identified by CD177 and CD275 show inverse activation of canonical and noncanonical WNT signaling. CD177+ ADE expresses and synthesizes the secreted WNT, NODAL and BMP antagonist CERBERUS1 and is specified toward the pancreatic fate. CD275+ ADE receives canonical Wnt signaling and is specified toward the liver fate. Isolated CD177+ ADE differentiates more homogeneously into pancreatic progenitors and into more functionally mature and glucose-responsive β-like cells in vitro compared with cells from unsorted differentiation cultures.

2020-04-27 | GSE113791 | GEO

Cd177

Project description:Rattus norvegicus Cd177, CD177 molecule [Source:RGD Symbol;Acc:1562941], is expressed in 3 baseline experiment(s);

| ENSRNOG00000022669 | ExpressionAtlas

CD177

Project description:Sus scrofa CD177, CD177 molecule [Source:VGNC Symbol;Acc:VGNC:86391], is expressed in 2 baseline experiment(s);

| ENSSSCG00000003051 | ExpressionAtlas

CD177

Project description:Homo sapiens CD177, CD177 molecule [Source:HGNC Symbol;Acc:HGNC:30072], is differentially expressed in 77 experiment(s);

| ENSG00000204936 | ExpressionAtlas

Cd177

Project description:Mus musculus Cd177, CD177 antigen [Source:MGI Symbol;Acc:MGI:1916141], is differentially expressed in 80 experiment(s);