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A highly conserved sRNA downregulates multiple genes, including a Sigma-54 transcriptional activator, in the virulence mode of Bordetella pertussis

ABSTRACT: Bacterial sRNAs together with the RNA chaperone Hfq post-transcriptionally regulate gene expression by affecting ribosome binding or mRNA cleavage. In the human pathogenBordetella pertussis, the causative agent of whooping cough, hundreds of sRNAs have been identified, but their roles inB. pertussisbiology are mostly unknown. We have performed RNA-seq analyses to determine gene expression changes forB. pertussisTohama Ivs.its derivative with a deletion of the Hfq-dependent sRNA S17, whose level increases dramatically in the virulence (Bvg+) mode.

ORGANISM(S): Bordetella pertussis Tohama I

PROVIDER: GSE277013 | GEO | 2025/08/20

REPOSITORIES: GEO

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