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Bordetella parapertussis shotgun proteomic analysis reveals physiological response to iron starvation and potential new virulence determinants absent in Bordetella pertussis

ABSTRACT: To our knowledge, we provide the first proteomics study of Bordetella parapertussis, one of the causative agents of whooping cough. We compared the identified proteins different to Bordetella pertussis, the other pathogen causing whooping cough. In addition, we extended the study to investigate the proteome response to iron limitation, a stress condition the pathogens face while infection.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Bordetella Parapertussis

TISSUE(S): Cell Culture

SUBMITTER: Kristin Surmann

LAB HEAD: Prof. Dr. Uwe Völker

PROVIDER: PXD012309 | Pride | 2020-02-05

REPOSITORIES: Pride

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Shotgun proteomic analysis of Bordetella parapertussis provides insights into the physiological response to iron starvation and potential new virulence determinants absent in Bordetella pertussis.

Oviedo Juan Marcos JM Surmann Kristin K Gorgojo Juan Pablo JP Valdez Hugo H Dhople Vishnu M VM Lamberti Yanina Y Völker Uwe U Rodriguez María Eugenia ME

Journal of proteomics 20190717

Bordetella parapertussis is one of the pathogens that cause whooping cough. Even though its incidence has been rising in the last decades, this species remained poorly investigated. This study reports the first extensive proteome analysis of this bacterium. In an attempt to gain some insight into the infective phenotype, we evaluated the response of B. parapertussis to iron starvation, a critical stress the bacteria face during infection. Among other relevant findings, we observed that the adapt ...[more]

PMID: 31325608

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