Characterization of tumour microenvironment landscape of mouse oral cancer tumours

ABSTRACT: Access of CD8+ T cells inside tumour nests is shaped by the tumour microenvironment (TME). Cancer-associated fibroblasts (CAFs) are among the most abundant TME components and have been associated with poor survival and T cells exclusion. However, the mechanisms that link CAFs presence with T cell blockade are unclear and there is a huge unmet medical need to increase T cell accessibility inside tumour cores. Here, we established single cell RNAseq of syngeneic murine models of head and neck squamous cell carcinoma that recapitulate different tumour-stroma organizations and evolutions (MOC1 and MOC2). MOC1 tumours are immune indolent and transition from a T cell infiltrated to an immune excluded/desert TME over time. MOC2 are more aggressive and are rich in myeloid cells while being T cell desert.

ORGANISM(S): Mus musculus

PROVIDER: GSE277135 | GEO | 2026/09/01

REPOSITORIES: GEO