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Bright light increases the severity of seizure through activating the GABAergic projection from ventral lateral geniculate nucleus to superior colliculus

ABSTRACT: Light has diverse effects on human well-being, with intriguing connections to both physiological and pathological brain processes. Bright light induces an aberrantly high activity of vLGNGABA neurons, which inhibits the neuronal excitability of postsynaptic SC neurons and suppresses termination of generalized seizure. Combined with single nucleus transcriptomic and electrophysiological analysis, we wanted to identify key genes.

ORGANISM(S): Mus musculus

PROVIDER: GSE282780 | GEO | 2025/10/01

REPOSITORIES: GEO

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