RNA interference screening identifies the Insulin/IGF-1 receptor pathway as a mechanism of escape from hormone dependence in breast cancer

ABSTRACT: A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. A kinome-wide siRNA screen identified a role for Insulin Receptor (InsR) in the hormone-independent growth of ER+ breast cancer cells We used gene expression microarrays to identify genes and pathways that are altered by insulin stimulation of ER+ MCF-7 human breast cancer cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE28580 | GEO | 2012/04/11

SECONDARY ACCESSION(S): PRJNA139131

REPOSITORIES: GEO