Transcriptomics

Dataset Information

18

RNA interference screening identifies the Insulin/IGF-1 receptor pathway as a mechanism of escape from hormone dependence in breast cancer


ABSTRACT: A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. A kinome-wide siRNA screen identified a role for Insulin Receptor (InsR) in the hormone-independent growth of ER+ breast cancer cells We used gene expression microarrays to identify genes and pathways that are altered by insulin stimulation of ER+ MCF-7 human breast cancer cells. Overall design: MCF-7 cells were treated with serum-free medium +/- insulin for 4 or 24 hrs prior to RNA harvest for analysis.

INSTRUMENT(S): [HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate

ORGANISM(S): Homo sapiens  

SUBMITTER: Todd W Miller   

PROVIDER: GSE28580 | GEO | 2012-04-11

SECONDARY ACCESSION(S): PRJNA139131

REPOSITORIES: GEO

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