Dataset Information


RNA interference screening identifies the Insulin/IGF-1 receptor pathway as a mechanism of escape from hormone dependence in breast cancer

ABSTRACT: A significant fraction of breast cancers exhibit de novo or acquired resistance to estrogen deprivation. A kinome-wide siRNA screen identified a role for Insulin Receptor (InsR) in the hormone-independent growth of ER+ breast cancer cells We used gene expression microarrays to identify genes and pathways that are altered by insulin stimulation of ER+ MCF-7 human breast cancer cells. Overall design: MCF-7 cells were treated with serum-free medium +/- insulin for 4 or 24 hrs prior to RNA harvest for analysis.

INSTRUMENT(S): [HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate

ORGANISM(S): Homo sapiens  

SUBMITTER: Todd W Miller  

PROVIDER: GSE28580 | GEO | 2012-04-11



Similar Datasets

2012-04-10 | E-GEOD-28580 | ArrayExpress
2010-06-15 | GSE19639 | GEO
2011-05-09 | GSE26834 | GEO
2011-05-09 | E-GEOD-26834 | ArrayExpress
2016-07-01 | E-GEOD-79492 | ArrayExpress
2008-11-20 | GSE7561 | GEO
2015-08-12 | E-GEOD-26834 | ExpressionAtlas
| GSE54171 | GEO
2016-10-25 | E-GEOD-78284 | ArrayExpress
2015-01-29 | E-GEOD-65398 | ArrayExpress