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Early malaria immune signatures in naïve adults experimentally infected with P.falciparum reveal high and low responders.

ABSTRACT: The immune response to Plasmodium falciparum (Pf) is complex and varies across individuals. A controlled human malaria infection (CHMI) study using Pf sporozoites (PfSPZ) was conducted to optimize administration methods and investigate early immune responses. Naïve volunteers were infected via intramuscular (IM) or direct venous inoculation (DVI), with varying parasitemia rates and pre-patent periods. Blood transcriptional profiling identified two distinct immune response profiles: high responders, with stronger and faster transcriptomic activation, and low responders, with weaker responses. These profiles correlated with differences in antibody levels, cytokine/chemokine responses, and dendritic cell phenotyping. High responders exhibited lower innate immune activation but stronger baseline T and B cell signatures. Understanding these early immune mechanisms may help identify pathways to enhance effective and lasting malaria immunity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE288609 | GEO | 2025/12/31

REPOSITORIES: GEO

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