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Single-cell Sequencing Analysis-driven Nanomedicine Design for Mimicking Endogenous Immune Repair in Myocardial Infarction

ABSTRACT: We present a data - driven biomimetic strategy. Single - cell RNA sequencing was used to analyze immune cell changes post - MI, uncovering macrophage subtypes' distinct roles at different recovery stages. Based on this, we developed immune cell - mimicking nanoparticles and a sequential delivery strategy to imitate the temporal distribution of M2a, M2b, and M2c macrophage subtypes in the MI repair process.

ORGANISM(S): Mus musculus

PROVIDER: GSE288676 | GEO | 2026/03/30

REPOSITORIES: GEO

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