Nanostring-Based Gene Expression Profiling of Melanoma Lymph Node Metastases

ABSTRACT: This study investigates gene expression profiles in metastatic melanoma lymph node samples using the Nanostring nCounter platform. Samples were obtained from patients who were treatment-naïve, resistant, or responsive to immune checkpoint inhibitor (ICI) therapy. We applied both the PanCancer Immune Profiling Panel and a custom tissue-resident memory (TRM) T cell panel to assess immune cell composition and activation states. The dataset reveals transcriptional signatures associated with ICI response, including enrichment of TRM-associated genes and interferon-stimulated pathways in responders, and immunosuppressive features in resistant tumors. These data provide insights into the role of tumour-resident T cells and the tumour immune microenvironment in shaping response to immunotherapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE294441 | GEO | 2026/06/08

REPOSITORIES: GEO