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Transcriptomic profiling of iPSC-derived microglia(iMGL) reveals FGL2-mediated Aβ uptake impairment and argatroban rescue associated with rs73375428 genotype.

ABSTRACT: To elucidate how the rs73375428 major allele impairs Aβ uptake and how argatroban rescues this impairment independently of thrombin inhibition, we performed RNA sequencing and bioinformatic analyses in iPSC-derived microglia(iMGL). These datasets provide insight into transcriptomic changes associated with FGL2 modulation and Alzheimer’s disease risk.

ORGANISM(S): Homo sapiens

PROVIDER: GSE295204 | GEO | 2026/04/21

REPOSITORIES: GEO

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Transcriptomic profiling of iPSC-derived microglia(iMGL) reveals FGL2-mediated Aβ uptake impairment and argatroban rescue associated with rs73375428 genotype.

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