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Small RNA sequencing of extracellular vesicles extracted from adipose tissue of healthy weight or obese human subjects

ABSTRACT: We identified EVs as novel regulatory factors that mediate adipose tissue–brain communication and are crucial for the central control of whole-body energy homeostasis. Our findings reveal that AT-EVs and their cargo microRNAs (miRNAs) are crucial regulators of central leptin sensitivity. To identify the specific subtypes of miRNAs that responsible for central leptin-sensitizing, we examined the sRNA profiles of EVs extracted from adipose tissue of healthy weight and obese subjects by RNA deep sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE295693 | GEO | 2026/04/10

REPOSITORIES: GEO

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