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Paternal methamphetamine exposure enhances methamphetamine susceptibility in male rat offspring

ABSTRACT: We previously demonstrated that male progeny of cocaine-experienced sires resisted cocaine, expressed as delayed acquisition of cocaine self-administration. Here, we sought to determine whether this phenotype extended to another psychostimulant, methamphetamine. Surprisingly, relative to saline-sired rats, male, but not female, methamphetamine-sired offspring demonstrated increased susceptibility to methamphetamine taking. Single nuclei RNA- and ATAC-sequencing of the nucleus accumbens was used to identify molecular drivers of phenotypes in cocaine- and methamphetamine-sired offspring. Sequencing results revealed unique profiles of gene expression and open chromatin in offspring nucleus accumbens. Differential gene expression in cocaine-resistant, cocaine-sired offspring and methamphetamine-susceptible, methamphetamine-sired offspring illuminates potential novel treatment targets for psychostimulant use disorders.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE296372 | GEO | 2026/08/12

REPOSITORIES: GEO

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	GSE296372_Rat_Transgen_NAc_scATAC_clusterRat_ArchRProject.tar.gz	Other
	GSE296372_Rat_transgen_multiomeRNA_refined_all_SeuratObj_N5.h5Seurat	Other

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