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Differentially expressed genes in HTR-8/SVneo cell overexpressing miR-26a-5p modulate invasion and migration

ABSTRACT: Aberrant expression of microRNAs (miRNAs) is a critical factor in the pathogenesis of preeclampsia (PE). miR-26a-5p is a key regulatory miRNA that plays an important role in trophoblast cell function, which is essential during placental development. This study aims to investigate the impact of miR-26a-5p overexpression on the transcriptome of trophoblastic HTR-8/SVneo cells, a commonly used model for studying trophoblast functions in placentas collected from pregnancies complicated by PE. In this study, HTR-8/SVneo cells were transfected with 75 nM miR-26a-5p mimics, and RNA sequencing (RNA-seq) was employed to analyze alterations in gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE297810 | GEO | 2026/05/18

REPOSITORIES: GEO

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