METTL3-dependent m6A methylation in atherogenic endothelial inflammation [RNA]

ABSTRACT: Atherosclerosis is initiated by endothelial inflammation. Using RNA-seq and eCLIP, we identified METTL3 as a mechanosensitive m6A writer that upregulates NLRP1 and downregulates KLF4 through YTHDF readers. Knockdown of METTL3 abrogated these changes and protected against flow-induced atherogenesis in vitro and in vivo.

ORGANISM(S): Homo sapiens

PROVIDER: GSE298180 | GEO | 2026/06/26

REPOSITORIES: GEO