Spatial transcriptomic profiling of ischemia-reperfusion injured mouse kidneys reveals niche-specific metabolic dysfunction

ABSTRACT: This study presents spatial transcriptomic data from mouse kidneys subjected to ischemia-reperfusion injury to investigate the molecular underpinnings of localized tissue responses. Using high-resolution Stereo-seq spatial transcriptomics, we profiled gene expression across healthy and injured renal microenvironments, focusing on areas surrounding failed repair proximal tubule (FR-PT) cells. Transcriptomic analysis revealed distinct niches characterized by downregulation of oxidative phosphorylation and fatty acid β-oxidation pathways, even in proximal tubule cells considered heatlhy.

ORGANISM(S): Mus musculus

PROVIDER: GSE298899 | GEO | 2026/08/27

REPOSITORIES: GEO