Transcriptomics

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RNA-seq of B-cell lymphoma treated with Ibrutinib and CAR T cells


ABSTRACT: This dataset presents RNA sequencing (RNA-seq) data from human B-cell lymphoma HT tumors established in immunodeficient mice. Tumors were treated with ibrutinib (IB), CD19-directed chimeric antigen receptor T cells (CAR T cells), or a combination of both. The study aimed to investigate transcriptomic changes and treatment-related gene expression differences induced by monotherapy or combination therapy. These data provide insight into the molecular responses to IB and CAR T-cell treatment in vivo and may help elucidate mechanisms underlying therapeutic synergy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE299395 | GEO | 2026/06/10

REPOSITORIES: GEO

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