Analysis of chromosomal structual aberratons in U-937 cell line

ABSTRACT: This Hi-C experiment was a part of a research which analyzed chromosomal structural aberrations in hematological malignancies. First, the author conducted comprehensive detection of fusion transcripts in RNA-seq data of DSMZ’s 99 cell lines, and then picked up cell lines with characteristic complex karyotype. U-937 cell line is one of them, which shows several characteristic “high-intensity bands” in contact maps. This Hi-C experiment revealed ectopic gene amplifications of cancer-associated genes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE300943 | GEO | 2026/06/14

REPOSITORIES: GEO