Effect of MEK inhibiton on KrasQ61R mutant Lgr5-positive intestinal stem cells

ABSTRACT: We have previously shown that KRAS hyperactivation depletes the Lgr5-positive intestinal stem cells. Here, we aim to address whether reducing the MAPK pathway output, by using a MEK inhibitor (Cobimetinib) is sufficient to restore expression of Lgr5-positive intestinal stem cell markers.

ORGANISM(S): Mus musculus

PROVIDER: GSE301567 | GEO | 2026/04/05

REPOSITORIES: GEO