Dysregulated Proline Metabolism Contributes to Subretinal Fibrosis in Neovascular AMD: Therapeutic Potential of Prolyl-4-Hydroxylase Inhibition

ABSTRACT: Subretinal fibrosis is a key pathological feature of late-stage neovascular age-related macular degeneration (nAMD), often leading to irreversible vision loss. To investigate early molecular changes underlying subretinal fibrosis, we performed transcriptomic analysis on JR5558 mice, a spontaneous model of retinal neovascularisation, at 4 and 8 weeks of age. Age-matched C57BL/6J mice were used as controls. Bulk RNA sequencing was performed on whole retinas to identify differentially expressed genes and enriched biological pathways.

ORGANISM(S): Mus musculus

PROVIDER: GSE301769 | GEO | 2026/08/10

REPOSITORIES: GEO