EIF4E2 Deficiency Drive Cisplatin Resistance in NSCLC

ABSTRACT: Cisplatin resistance remains a major obstacle in treating non-small cell lung cancer (NSCLC). Mechanistic insights into the translational control of cisplatin resistance remain sparse. This study identifies eIF4E2 as a critical translational regulator whose downregulation elevates DNA repair capacity and drives cisplatin resistance.

ORGANISM(S): Homo sapiens

PROVIDER: GSE303283 | GEO | 2026/03/24

REPOSITORIES: GEO