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Transcriptome profiling of wild-type C. elegans and strains expressing wild-type or G2019S-mutant human LRRK2

ABSTRACT: This study presents RNA sequencing data from Caenorhabditis elegans strains expressing human wild-type or G2019S-mutant LRRK2 in a pan-neuronal manner, as well as wild-type control animals. Samples were collected to investigate the transcriptomic effects of LRRK2 expression and mutation on aging-related biological processes. Total RNA was extracted from synchronized animals, and libraries were sequenced using the Illumina NovaSeq 6000 or MGISEQ-T7 platform. Clean reads were aligned to the C. elegans reference genome (WBcel235), and gene expression levels were quantified as FPKM.

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE305282 | GEO | 2026/08/01

REPOSITORIES: GEO

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