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Transcriptomic profiling of blood neutrophils from preterm infants with bronchopulmonary dysplasia

ABSTRACT: Bronchopulmonary dysplasia (BPD) is a major complication of preterm birth, yet its immune mechanisms remains poorly understood. To explore the role of neutrophils in the pathogenesis of BPD, a prospective study was conducted in the Neonatal Intensive Care Unit of Guangzhou Women and Children’s Medical Center from June to September 2024. Inclusion criteria were: (1) preterm birth at <32 weeks of gestational age, and (2) admission within 6 hours after birth. Peripheral blood samples were collected on day 14 after birth. Infants with major congenital anomalies or acute infections were excluded. A total of 22 preterm infants were enrolled, of whom 12 developed BPD. Neutrophils were isolated from peripheral blood, and bulk RNA sequencing was performed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE305315 | GEO | 2026/08/13

REPOSITORIES: GEO

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	GSE305315_TPM_all_samples.csv.gz	Csv
	GSE305315_counts_all_samples.csv.gz	Csv

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