UV induced translation capacity is developmentaly regulated in fungi
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ABSTRACT: In fast-growing cells, most RNA molecules encode ribosomal subunits. During growth arrest caused by DNA damage, ribosome biogenesis is reduced because it is an highly energy demanding process. Here we report that, in two filamentous fungi, UV radiation significantly induces ribosome levels and translation capacity. This UV-induced response is developmentally regulated, occurring mosly after filament formation. Translation induction modestly enhances both UV survival and repair. Most of the mRNAs that are differentialy associated with ribosomes following UV exposure belong to modules involved in protein folding and gene expression, not only DNA repair. Furthermore, UV-induced translation is dependent on PKA signaling but remains unaffected by Target Of Rapamycin inhibition. These findings suggest a novel type of fungal response to DNA damage, where the primary aim is to protect the integrity of tgene expression from the detrimental effects of UVon transcription
ORGANISM(S): Fusarium oxysporum Fusarium mangiferae
PROVIDER: GSE305365 | GEO | 2025/08/16
REPOSITORIES: GEO
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