Deep sequencing of gonadal white adipose tissue (gWAT) from Floxed Control (WT), adipocyte-specific Gα13 knockout (Gα13 AKO), and Gα12/13 double knockout (Gα12/13 DKO; Gα13 AKO combined with global Gα12 deletion) mice

ABSTRACT: The therapeutic relevance of GPCR-targeting drugs has expanded, yet the function of Gα12/13 in adipose tissue remain incompletely understood. This study investigated the metabolic roles of Gα12/13 in adipocytes under conditions of diet-induced obesity. Transcriptomic profiling was performed on gonadal white adipose tissue collected from Floxed Control (WT), adipocyte-specific Gα13 knockout (Gα13 AKO) mice and double knockout mice (Gα12/13 DKO; Gα13 AKO combined with global Gα12 deletion) after 16 weeks of normal chow diet (NCD) or high-fat diet feeding (HFD).

ORGANISM(S): Mus musculus

PROVIDER: GSE305870 | GEO | 2026/08/28

REPOSITORIES: GEO