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RNA-seq analysis of spiral ganglion neurons treated with cisplatin and dimethyl fumarate to elucidate otoprotective mechanisms

ABSTRACT: This study aims to elucidate the potential protective mechanisms of dimethyl fumarate (DMF) against cisplatin-induced ototoxicity at the transcriptomic level. Spiral ganglion neurons (SGNs) were divided into two treatment groups: cisplatin alone and cisplatin combined with DMF. Gene expression profiling was performed using high-throughput RNA-sequencing. Differential expression analysis identified a set of significantly upregulated and downregulated genes in the DMF combination group compared to the cisplatin-only group. Pathway enrichment analysis highlighted significant alterations in autophagy and mitophagy pathways, suggesting that DMF may alleviate cisplatin-induced damage by modulating these processes in SGNs. This dataset provides the raw sequencing reads (FASTQ) and gene count matrix, serving as a valuable resource for investigating drug-induced ototoxicity and protective therapeutic strategies.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE308431 | GEO | 2026/09/15

REPOSITORIES: GEO

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Diet modulates the protective effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCA2

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