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A non-canonical transcriptional regulation in natural product biosynthesis

ABSTRACT: TenA-family proteins are widespread bacterial regulators with unknown roles in natural product biosynthesis. This study aimed to functionally characterize LysR2, a TenA-family protein in Actinobacteria, and elucidate its mechanism in regulating the production of lysolipin I. We demonstrate that LysR2 represents a novel type of regulator that controls antibiotic biosynthesis not by direct DNA binding, but through protein-protein interactions, specifically by antagonizing the repressor LysR1. This work reveals an unconventional regulatory strategy, expanding the mechanistic understanding of transcriptional networks in natural product formation.

ORGANISM(S): Streptomyces auratus

PROVIDER: GSE309193 | GEO | 2025/09/30

REPOSITORIES: GEO

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