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Bulk RNA sequencing of liver NK cells and ILC1s from T-bet WT vs. inducible Ncr1-T-bet Δ/Δ mice

ABSTRACT: The role of the T-box transcription factors T-bet and Eomes in innate lymphoid cells (ILCs) beyond their development is not well understood. We generated an inducible, NKp46 (Ncr1)-specific T-bet floxed knock-out mouse (Ncr1-T-betΔ/Δ) model. Bulk RNA sequencing of liver NK cells after tamoxifen treatment from T-bet WT (NKp46-CreERT2 x T-bet fl/fl) vs. Ncr1-T-bet Δ/Δ (NKp46-CreERT2 x T-bet fl/fl) mice had minimal transcriptional changes, whereas T-bet-deficient ILC1 exhibited significant gene expression changes. This sequencing data along with their rapid loss in vivo in Ncr1-T-betΔ/Δ mice reveal the requirement for continuous T-bet expression in liver ILC1.

ORGANISM(S): Mus musculus

PROVIDER: GSE309461 | GEO | 2026/04/06

REPOSITORIES: GEO

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Bulk RNA sequencing of liver NK cells and ILC1s from T-bet WT vs. inducible Ncr1-T-bet Δ/Δ mice

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