Genomics

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MBD3 regulates thymic Treg precursor cell development by modulating CD25 expression [ChIP-seq]


ABSTRACT: ChIP-seq was performed in wild-type (WT) thymocytes to profile MBD3 occupancy and histone modifications, including H3K27ac and H3K4me1. These data reveal direct binding of MBD3 to Treg-specific regulatory regions and co-localization with activating histone marks. In Mbd3 conditional knockout (CKO) thymocytes, these regulatory regions exhibit altered chromatin modifications, correlating with impaired thymic Treg differentiation. These ChIP-seq datasets provide a multi-omic view of how MBD3 binding and associated histone modifications contribute to thymic Treg lineage specification.

ORGANISM(S): Mus musculus

PROVIDER: GSE310014 | GEO | 2026/09/29

REPOSITORIES: GEO

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