MRNA-seq profiles of HL-1 cardiomyocytes of Tachypacing and Non-tacypacing and with or without NAD+ and βOHB treatment

ABSTRACT: We found that Tachypacing stimulation induced a metabolic shift from fatty acid oxidation (FAO) to glycolysis, along with mitochondrial dysfunction, oxidative stress, repressed mitophagy, and activated NLRP3 inflammation. Both NAD⁺ and βOHB significantly prevented mitochondrial and metabolic remodeling.

ORGANISM(S): Mus musculus

PROVIDER: GSE311341 | GEO | 2026/09/15

REPOSITORIES: GEO