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RNA-Seq analysis of 2C genes following MERVL-NELFA overexpression in wild type mESCs

ABSTRACT: Zygotic genome activation (ZGA) in early embryos is driven by extensive chromatin remodeling initiated by maternal factors, enabling the activation of cleavage-stage gene programs that underpin totipotency. In mouse embryonic stem cells (mESCs), a similar 2-cell-like (2C) state can be induced experimentally through the expression of specific maternal regulators such as NELFA. The RNA-seq dataset here was used to estimate the impact of NELFA-MERVL overexpression on of 2C characteristic genes in mESCs.

ORGANISM(S): Mus musculus

PROVIDER: GSE311871 | GEO | 2026/07/27

REPOSITORIES: GEO

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RNA-Seq analysis of 2C genes in mESC lines with overexpression of full length NELFA, MERVL-NELFA and IDR-deletion mutant (NELFA-IDR-Del).

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