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Bulk RNA Seq of Mouse RPE/Choroid from AAV-overexpressed IFN-beta and Control

ABSTRACT: Type-I IFNs have been implicated in the development and progression of retinal disease, however the concequence of long term ocular exposure to Type-I IFN and the cell types that are impacted has not been characterized. This study uses AAV2 to overexpress IFN-beta to achieve prolonged retinal exposure with a single intravitreal injection. We have then employed a bulk RNA to examine the response of the RPE and choroidal cells to prolonged Type-I IFN exposure.

ORGANISM(S): Mus musculus

PROVIDER: GSE313587 | GEO | 2026/04/01

REPOSITORIES: GEO

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Single Cell RNA Seq of Mouse Retina from AAV-overexpressed IFN-beta and Control

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mouse RPE/choroid age comparison - ATLAS arrays

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In vivo Gene Expression Profiling of RPE/choroid Post-Intravitreal Injections of Dexamethasone and Triamcinolone at Clinically Relevant Time Points for Patient Care

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