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Microarray analysis of quadriceps muscle of fed or 24 h-fasted wild type mice and skeletal muscle-specific FoxO1,3,4 knockout mice

ABSTRACT: Catabolic conditions, such as starvation, inactivity, and cancer cachexia, induce Forkhead box O (FoxO) transcription factor(s) expression and severe muscle atrophy via the induction of ubiquitin–proteasome system-mediated muscle proteolysis, resulting in frailty and poor quality of life. Microarray analysis of quadriceps muscle of fed or 24 h-fasted wild type mice and skeletal muscle-specific FoxO1,3,4 knockout mice identified the potential novel FoxOs-target genes in skeletal muscle including Redd1, Sestrin1, Castor2, Chac1, Depp1, Lat3, as well as Cebpd. This study comprehensively identifies novel potential FoxOs-target genes in skeletal muscle and clarifies the pathophysiological role of FoxOs, master regulators of skeletal muscle atrophy.

ORGANISM(S): Mus musculus

PROVIDER: GSE314981 | GEO | 2026/04/20

REPOSITORIES: GEO

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