Compartment specific mitochondrial unfolded protein response

ABSTRACT: Alzheimer’s disease lacks effective disease‑modifying treatments partly because early, compartment‑specific mitochondrial stress responses in microglia remain poorly defined. Our findings show that APP expression and targeted activation of UPRmt-MM or UPRmt-IMS produce distinct transcriptional signatures—ranging from immune activation and impaired oxidative phosphorylation to disrupted mitochondrial ribosome integrity—highlighting mitochondrial compartmentalization as a key driver of AD pathogenesis and a potential therapeutic target.

ORGANISM(S): Homo sapiens

PROVIDER: GSE315336 | GEO | 2026/09/09

REPOSITORIES: GEO