The role of Voclosporin administration and Inmt TG in renal proximal tubules.

ABSTRACT: Indolethylamine N-methyltransferase (Inmt), an enzyme responsible for detoxifying local uremic toxins, including indole. We next investigated a strategy for preventing the significant decrease in Inmt expression in proximal tubules induced by high‑dose Voc administration and I/R. Accordingly, we used transgenic (Tg) mice with proximal tubule-specific Inmt overexpression and comparatively analyzed the changes with WT mice. Both WT and Tg mice were treated with high‑dose Voc, followed by I/R or sham operation for controls. Two experimental groups were campared using RNA-seq as follows: 1. I/R+WT+Voc (WT mice subjected to I/R and treated with high‑dose Voc)=WT+AKI, 2. I/R+Tg+Voc (Tg mice subjected to I/R and treated with high‑dose voclosporin)=TG+AKI. Results: Inmt-overexpressing mice treated with high-dose voclosporin exhibited absence of peroxisomal abnormalities and resistance to I/R injury.

ORGANISM(S): Mus musculus

PROVIDER: GSE316216 | GEO | 2026/03/28

REPOSITORIES: GEO